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CEPI assists in the advancement, development and manufacture of COVID-19 vaccine

Bio E initiated a Phase 1/2 clinical trial to evaluate the safety and immunogenicity of the vaccine candidate in India in November 2020, and expects interim data from the trial to be available in Q1 of 2021.

by Admin
December 30, 2020
in Covid-19, Featured, Health, Insights, News, Vaccine, World
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CEPI assists in the advancement, development and manufacture of COVID-19 vaccine
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  • Bio E initiated a Phase 1/2 clinical trial to evaluate the vaccine candidate’s safety and immunogenicity in India in November 2020 and expects interim data from the trial to be available in Q1 of 2021.

THD NewsDesk, New Delhi: The Coalition for Epidemic Preparedness Innovations (CEPI) and Biological E, India announced a collaboration to advance the development and manufacture of Biological E’s COVID-19 subunit vaccine candidate. CEPI will initially contribute up to $5 million toward the cost of scaling up the process for manufacturing the vaccine and will explore providing additional funding to Bio E to enable the production of 100 million doses in 2021 potentially. The candidate has also received seed funding from the Department of Biotechnology, Government of India.

Bio E initiated a Phase 1/2 clinical trial to evaluate the vaccine candidate’s safety and immunogenicity in India in November 2020 and expects interim data from the trial to be available in Q1 of 2021.

CEPI’s investment will be made available for procurement and allocation, if proven to be safe and effective, through the COVID-19 Vaccine Global Access (COVAX) Facility. The COVAX Facility aims to ensure equitable access to COVID-19 vaccines for all countries at all development levels that wish to participate.

Big E’s COVID-19 vaccine candidate is based on classical vaccine technology of a protein antigen, SARS-CoV-2 Spike RBD, adsorbed to the adjuvant Alhydrogel (Alum), in combination with another approved adjuvant, CpG 1018. The RBD of the S1 subunit binds to the Angiotensin-Converting Enzyme-2 (ACE2) receptor on the host cell membrane and facilitates virus entry.

RBD protein is expressed in yeast Pichia pastoris and is similar to technology Bio E is employing for large-scale commercial Hep B vaccines production. The Baylor College of Medicine constructs “RBD N1C1” was selected as the final vaccine antigen candidate based on its manufacturability due to the yields of protein antigen achieved, ease of process steps, and favorable formulation aspects.

The combination of Alum with CpG with N1C1 antigen elicited a highly synergistic, balanced immune response in preclinical models. Four formulations with these components are currently being evaluated in Phase I/ II clinical study in India to select the final vaccine candidate to be tested in subsequent Phase III trials.

Source: ExpressPharma

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