A new study determined that people who take the SGLT2 inhibitor class of diabetes medications face a higher risk of diabetic ketoacidosis (DKA).
The study found that people who take SGLT2 inhibitor drugs face a higher DKA risk than those who take DPP-4 inhibitors. The study also found that the drug could cause infections.
The study demonstrates that DKA seems to be a side effect of SGLT2 inhibitor drugs, according to Kristian Filion of the Lady Davis Institute at Jewish General Hospital in Montreal, Canada.
“There was some uncertainty about how much the risk of DKA was, so we wanted to get a more precise estimate of the risk. We found a threefold increased risk,” Filion said.
SGLT2 inhibitors make the kidneys get rid of blood sugar via urination, lowering blood sugar levels, according to the U.S. Food and Drug Administration. Insulin production also slows when the blood sugar is lowered, according to NYU Langone Health’s Dr. Akankasha Goyal. The body needs insulin to transport sugar from blood to cells.
The body uses stored fat for energy when insulin levels are low. Ketones result from this, according to the American Diabetes Association. Ketone build-up in the blood can cause DKA.
“DKA is a diabetic emergency. Someone in DKA needs to be hospitalized,” Goyal said. While this condition is uncommon in type 2 diabetics, it can be fatal if left untreated.
The study involved over 200,000 patients who used SGLT2 inhibitors from 2013 to 2018. They were compared with a matched patient cluster who took DPP-4 inhibitors.