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UK Clinical Trial Confirms SaNOtize’s Nitric Oxide Nasal Spray (NONS) as an effective antiviral treatment to prevent the transmission of COVID-19

by Ashutosh Jha
March 16, 2021
in Covid-19, Drug, Testing
Reading Time: 4 mins read
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SaNOtize’s Nitric Oxide Nasal Spray (NONS) as an effective antiviral treatment
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THD NewsDesk, New Delhi: SaNOtize’s Nitric Oxide Nasal Spray (NONS) represents a safe and effective antiviral treatment that could prevent the transmission of COVID-19 and with those already infected, it reduces the severity of symptoms and damage in those already infected.

This was announced by top medical research today while commenting on results of clinical trials that is VANCOUVER, British Columbia & SURREY, England (BUSINESS WIRE), Biotech company SaNOtize Research & Development Corp (SaNOtize), Ashford and St Peter’s Hospitals NHS Foundation Trust in Surrey, UK, and Berkshire and Surrey Pathology Services, UK.

What is SaNOtize?

SaNOtize Research & Development Corp. is a biotech company based in Vancouver, BC working to commercialize the multi-faceted antimicrobial properties of a liquid producing nitric oxide. The company has developed and patented a Nitric Oxide Releasing Solution platform technology (NORSTM) to treat and prevent microbial infections.

The average viral log reduction in the first 24 hours was 1.362, which corresponds to a decline of about 95%. Within 72 hours, the viral load dropped by more than 99%. In a randomized, double-blind, placebo-controlled Phase 2 trial that evaluated 79 confirmed cases of COVID-19, SaNOtize’s early treatment for COVID-19 significantly reduced the level of SARS-CoV-2, including in patients with high viral loads.

The majority of these patients had been infected with the UK variant, which is considered a variant of concern. However, no adverse health events is recorded in the UK trial, or in over 7,000 self-administered treatments given in earlier Canadian clinical trials.

Monoclonal antibodies are highly specific, expensive and must be administered intravenously in a clinical setting. Therefore, NONS is the only novel therapeutic treatment so far proven to reduce viral load in humans that is not a monoclonal antibody treatment.

Dr. Stephen Winchester, Consultant Medical Virologist and Chief Investigator of this NHS Clinical Trial said “This simple portable nasal spray could be highly effective in the treatment of COVID-19 and reducing onward transmission. I expect this to be a major advance in the global battle against the devastating human impacts of the COVID-19 pandemic. Our trial included patients with a variant of concern and high viral loads yet still demonstrated significant reductions in the levels of SARS-CoV-2, which could be critical in supporting vaccines, preventing future outbreaks and safely reopening economies.”

The SaNOtize treatment is designed to kill the virus in the upper airways, preventing it from incubating and spreading to the lungs. It is based on nitric oxide (NO), a natural nano molecule produced by the human body with proven anti-microbial properties shown to have a direct effect on SARS-CoV-2, the virus that causes COVID-19. The NO molecule released from NONS is identical to the one delivered in its gaseous form to treat persistent pulmonary hypertension, or Blue Baby Syndrome, in newborn babies.

SaNOtize to seek Emergency Use Authorization in UK and Canada

Swift approval and ramp-up of manufacturing could facilitate an almost immediate safe return to work, school and society, and spur an economic recovery that is months, if not years, ahead of full global vaccination.

The ease of NONS manufacture, storage and use makes NONS a treatment candidate that could soon be widely available at low-cost for long-term care facilities, healthcare and frontline workers, and the general population. Wide-scale equitable global availability of NONS could form a bridge during the global production and distribution of vaccines to help keep people safe and healthy.

NONS has also demonstrated that it could also reduce infectivity, in addition to providing antiviral treatment in the early stages of infection and for those who have yet to be vaccinated.

From SaNOtize’s earlier Phase 2 trials in Canada and an independent lab tests at Utah State University’s Antiviral Research Institute, the results of the UK trial corroborate the information gathered so far.

“We must move with urgency to get NONS into the hands of the public after it has been demonstrated to be safe and effective in clinical trials where it can help bring an end to the pandemic, accelerate a return to normality, and prevent future outbreaks of COVID-19 and its variants,” said Dr. Gilly Regev, CEO and co-founder of SaNOtize.

“The human toll of this disease cannot be expressed simply in numbers, and each day compounds the frustration, fear and loss suffered by millions around the world. Combined with the roll-out of vaccines, NONS can help get the world back on its feet”, added Dr. Gilly Regev

Details about Double-Blind, Placebo-Controlled, Phase 2 Clinical Trial

To determine the clinical efficacy of NONS for the treatment of mild COVID-19 infection, the study was conducted by Dr Stephen Winchester and Dr Isaac John at Ashford and St. Peter’s Hospitals NHS Foundation Trust.  The primary outcome measure was the difference in SARS-CoV-2 RNA load from baseline through Day 6 between NONS and control arms.

Dr. Chris Miller, Chief Science Officer and co-founder of SaNOtize said “There is currently a lack of an antiviral therapy that is effective against COVID-19 and its variants, can prevent or shorten the course of the disease, reduce damage, lower the severity of COVID-19, and can be made widely and readily available to the public. This is what makes NONS unique and enables it to stand alone from any other novel therapeutic application.”

 “NONS destroys the virus, blocks entry into and halts viral replication within the nasal cavity, which rapidly reduces viral load. This is significant because viral load has been linked to infectivity and poor outcomes” added Dr. Chris Miller.

The rigor of this trial and the decades of safety data behind nitric oxide give us full confidence in requesting emergency use approval in the UK, Canada and elsewhere in the world.

Rob Wilson, SaNOtize’s UK representative said “We are pleased to have conducted this crucial trial in the NHS and now hope that regulators will play their part in arming the public in the battle against this devastating disease.”

Ashutosh Jha

Ashutosh Jha

Ashutosh has a Bachelors Degree in English Literature from the University of Delhi. His capabilities as a writer transcend into literally every genre available. A procrastinator, liquor connoisseur, and collector of fine books, he vociferates in equal decibels while reading Oscar Wilde or Mirza ‘Ghalib’. When not trying to usher in a Utopia, Ashutosh pens Urdu couplets by the nom de plume of ‘Naqqash’.

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