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Pfizer’s coronavirus candidate proves to be reliable

Pfizer’s coronavirus vaccine candidate gives reliable protection after the initial dose.

by Antara Adhikari
December 9, 2020
in News, Covid-19, Featured, Health, HealthTech, Insights, Reports, Spotlight, Vaccine, World
Reading Time: 3 mins read
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  • Pfizer and BioNtech vaccine candidates have proven to render strong protection against COVID-19.
  • Pfizer and BioNTech announced that their two-dose vaccine had an efficacy rate of 95% after two doses administered three weeks apart.
  • Pfizer and BioNTech observed that people over 65 got about as much strength from the coronavirus vaccine as younger people did.

THD NewsDesk, New Delhi: Pfizer and BioNtech vaccine candidates have proven to render strong protection against COVID-19 within the very first ten days of the first dose. This information was established by the Food and Drug Administration’s released document before a meeting of its vaccine advisory group. 

The finding is significant in the briefing material, which spans 53 pages of data analyses from the agency and Pfizer. Last month, Pfizer and BioNTech announced that their two-dose vaccine had an efficacy rate of 95% after two doses administered three weeks apart. The new analyses show that the protection starts kicking in far earlier.

To our surprise, the vaccine served well despite a volunteer’s race, weight, or age. While on the one hand, the trial did not record serious adverse effects created by the vaccine, many volunteers underwent aches, fevers, and other side effects.

On Thursday, the FDA’s vaccine advisory panel will discuss these substances in the progression of a vote on whether to approve Pfizer’s sanction and BioNTech’s vaccine.

Pfizer and BioNTech commenced a massive clinical trial in July, enlisting 44,000 individuals in the United States, Brazil, and Argentina. Half of the volunteers received the vaccine, and half acquired the placebo.

As per one graph in the briefing elements, new coronavirus cases promptly decreased in the immunized assortment of volunteers about ten days after the first dose. In the placebo group, cases kept unwaveringly increasing.

The vaccine’s sudden influence could serve not just the people who get it but also the country’s congested hospitals, restraining new patients’ admittance into intensive care units.

Notwithstanding the preceding protection provided by the first dose, it’s uncertain how longspun the protection would serve on its own, emphasizing the significance of the following dose. Former investigations have discovered that the second dose of the Pfizer-BioNTech vaccine provides the immune arrangement a major, long-term boost, an effect noticed in many other vaccines.

Several authorities have shown concern that the coronavirus vaccines might preserve some people better than others. But the results in the briefing materials indicate no such obstacle. The vaccine has an extraordinary efficiency rate in both men and women and similar white, Black, and Latino people. It also worked well in overweight people, who carry a more major hazard of getting infected with COVID-19.

Some vaccines for other diseases set off a weak immune response in older adults. But Pfizer and BioNTech observed that people over 65 got about as much strength from the coronavirus vaccine as younger people did.

Even if the FDA approves the vaccine, the trial will advance. In the briefing documents, the companies declared that they would support people to stay in the trial as long as feasible, irrespective of whether they received the vaccine or the placebo.

The new data revealed that many volunteers who received the vaccine felt ill in the hours after the second dose, suggesting that many people might have to request a day off work or be prepared to rest until the symptoms subside. Among those between ages 16 and 55, more than half developed fatigue, while 59% reported headaches. Just over one-third felt chills, and 37% felt muscle pain. About half of those over age 55 felt fatigued, one-third developed a headache, and about one-quarter felt chills, while 29% experienced muscle pain.

On Monday, Kristen Choi, a psychiatric nurse and health services researcher at the University of California, Los Angeles, published a first-person account of the symptoms she experienced as a participant in the Pfizer-BioNTech trial.

“Clinicians will need to be prepared to discuss with patients why they should trust the vaccine and that its adverse effects could look a lot like COVID-19,” Choi wrote in the journal JAMA Internal Medicine. She advised doctors to tell patients that these unpleasant symptoms were “a sign that the vaccine is working, despite the unfortunate similarities with the disease’s symptoms,” Choi said. 

 

Source: The Indian Express 

 

 

Antara Adhikari

Antara Adhikari

Antara is a women's rights activist and a Master of Social Work student at the Tata Institute of Social Sciences, Mumbai. She has always been intrigued by society's socio-cultural and economic intersections and its bearing on people's lives. To advocate for the excluded and bring forth the million feeble voices through her writing remains at the centre of her heart. Along with being an avid music enthusiast, she relishes reading and writing poetry.

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